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Comment by superpermutat0r

It all depends on the context.

There is no reason why your body should use the supplement vitamins or minerals if your diet is normal (not deficient). For example, a lot of people eat a bunch of animal products rich in calcium, D3, protein etc. and end up with diseases like osteoporosis, sarcopenia etc. Even with real food their bodies did not do anything with it.

Intervention studies with supplements on these kinds of people show that they rarely help or help very little (not long-term).

You need to make your body use the stuff you give it.

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