Comment by hcrisp

Have you looked at pyfive [0], h5s3 [1], or Kita [2]? What about version 2.9 of h5py [3] which supports file-like object access?

  [0] https://github.com/jjhelmus/pyfive
  [1] https://h5s3.github.io/h5s3/python.html
  [2] https://www.hdfgroup.org/solutions/hdf-kita/
  [3] http://docs.h5py.org/en/stable/high/file.html#python-file-like-objects