Comment by w33ble

I do this, though not from Windows, just Mac and Linux. I use restic, which has B2 support smd handles all the encryption. it also does diffing for backups. There's a Windows build, so I assume it would work for you there as well.

You can view and download builds at https://github.com/restic/restic/releases/

I don't automate this though, I just use it for occasional backups. Not sure what the automation story around restic is.