Comment by emersonrsantos

As with all drugs, it's not understood the paradoxical drug effects. Stimulants can make people sleepy, and the most potent of benzodiazepamines can make one more agressive. The endocrine system (also the immune system) is so complex and so full of variables and network effects that I think that science has a long way ahead for a precise scientific understanding of all the positive and negative effects of these drug categories.