<Space-flown hiPSC-CMs [human induced pluripotent stem cell-derived cardiomyocytes] exhibited unchanged Ca2+ transient amplitude but showed a significant increase in transient decay tau (Figures 3E and S1) that is indicative of a decreased calcium recycling rate.
We also observed an increase in the standard deviation of beating intervals (Figure 3F) in space-flown hiPSC-CMs, indicating beating irregularity.
These results suggest that calcium-handling-related parameters remain altered for space-flown hiPSC-CMs following return to normal gravity.>
We also observed an increase in the standard deviation of beating intervals (Figure 3F) in space-flown hiPSC-CMs, indicating beating irregularity.
These results suggest that calcium-handling-related parameters remain altered for space-flown hiPSC-CMs following return to normal gravity.>