I've been using an Akitio Node + WX8200 (Vega 56 Pro, needed to drive 2x 5k monitors) for about 7 months now on my daily driver (2018 i9 32gb 15" macbook pro) and I haven't had any real issues with disconnecting. There are only two annoyances:
1) Sometimes an app won't quit that's using the external GPU prevent me from safely disconnecting. This is annoying when you have to run to a meeting and don't want to risk the system crashing.
2) If you connect the eGPU when apps are already running, they'll continue to be rendered on the internal GPU. This is probably OK for most people, but the internal GPU can't drive 2x 5k displays, so although it works they're really laggy until they're relaunched.
Other than those two issues, I highly recommend this setup to everyone. I actually have 2 egpus, the other has a 1080ti that I use for light ML work and gaming on linux and windows respectively.
1) Sometimes an app won't quit that's using the external GPU prevent me from safely disconnecting. This is annoying when you have to run to a meeting and don't want to risk the system crashing.
2) If you connect the eGPU when apps are already running, they'll continue to be rendered on the internal GPU. This is probably OK for most people, but the internal GPU can't drive 2x 5k displays, so although it works they're really laggy until they're relaunched.
Other than those two issues, I highly recommend this setup to everyone. I actually have 2 egpus, the other has a 1080ti that I use for light ML work and gaming on linux and windows respectively.