Ask HN: What is the best setup to work remotely with GUI on Linux?

In the past I tried a couple of setups using different protocols (VNC / RDP) with varying server / client software but was never really satisfied. Since this is a common problem, I am sure that some people here on HN have a well tested configuration for this and might be willing to give some advice.

Scenario I am interested in: * Server machine runs graphical applications (potentially GPU / OpenGL intensive) * Client can connect via SSH and is supposed to see graphical application (full desktop or just application)

Thanks for any recommendation!