I believe `<main>` is not supported in IE11 - here is a resource that you can use to check HTML5 accessibility compatibility: https://www.html5accessibility.com/
The tricky thing about when you're talking about screen readers is that you now have to take into account browser support AND screen reader support, which can sometimes multiply the amount of test cases for things.
The tricky thing about when you're talking about screen readers is that you now have to take into account browser support AND screen reader support, which can sometimes multiply the amount of test cases for things.