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Comment by jboggan
I was going to give a lecture across several departments about my PhD research in bioinformatics. The night before the talk I was generating some new figures and saw something weird, which led to me digging through source code and discovering a bug which invalidated the last 18 months of research and all my conclusions. I went to my advisor with this problem and he told me to present it anyways. I refused. I suffered consequences for that, including getting stonewalled by my advisor whenever I tried to publish a paper. I wish I had actually been in a position to refuse.