Comment by Madmallard

I think in several cases the cause can be traced to taking multiple courses of ciprofloxacin or other fluoroquinolones which have been known to be mitochondrial topoisomerase poisons for decades. The drugs are super dangerous for public health and should be reserved for last resorts and the medical industry is finally catching on.

If you ruin the mitochondrias ability to reproduce you will develop latent muscular and neurological dysfunction.