Did you ever tried org-mode with org-babel? If not only see few video about org-mode reproducible research / emacs on YT&c :-) in terms of reproducibility Nix{,OS} and Guix{,SD} offer really nice tools to achieve full-stack reproducibility without the need of publish multi-Mb/Gb archives, only a text file .nix or scheme can do the business.
Also ESS inside Emacs it's another nice working environment, perhaps is not as "natural at first impact" like a spreadsheet but I bet NO ONE after a week of (self) training will found spreadsheet better or even usable.
Also ESS inside Emacs it's another nice working environment, perhaps is not as "natural at first impact" like a spreadsheet but I bet NO ONE after a week of (self) training will found spreadsheet better or even usable.