I'm exploring Nest [0] for my next project. It is a "glue framework" on top of Typescript and many Node libraries, with an Angular like style.
Every Node library used has a framework module which provides the integration with the framework [1] so it appears to be both flexible and easy to use.
I am just starting to explore Nest and I'm liking it, my previous experience on the backend was on Django for many years and Nest seems like a breath of fresh decoupled air, coming from this heavy monolithic experience.
[0] https://nestjs.com/
[1] https://github.com/nestjs