If there's no clear and abiding biological cause (like in general paresis or something), nearly all psychological disease is culture-bound.
America in 1950 had orders of magnitudes less diagnosed depression than America in 2018, although people had some things that we would label depression today - and that Americans of 2050 will doubtless label something interesting and different.
America in 1950 had orders of magnitudes less diagnosed depression than America in 2018, although people had some things that we would label depression today - and that Americans of 2050 will doubtless label something interesting and different.