"Modern" desktop environments of course do have file type associations, but this is unrelated to binfmt_misc.
I can't think of any realistic threat model in which binfmt_misc would reduce security. If you are running untrusted code, it doesn't matter it's an ELF, a shell script, or a VBS script ran through Wine. It's game over anyway.
I can't think of any realistic threat model in which binfmt_misc would reduce security. If you are running untrusted code, it doesn't matter it's an ELF, a shell script, or a VBS script ran through Wine. It's game over anyway.