Ask HN: How has working remotely for long periods affected your social skills?

This question is mainly directed at people who work all their hours remotely and have no hours working in person at an office. Especially if you've worked this way for several months or years, how has it affected the way you interact with people? Has it made some things more difficult to you? In particular if you are living single, and aren't living with anyone to take care of (no SO, or no children or other family).