If you're targeting a mid-sized company or bigger, your resume will most likely first be parsed[1], with key skills, education, years of experience (etc) extracted and stored in some kind of applicant tracking system, and then loosely searched against. Your resume will likely not be looked at by human eyes until it passes through this filter, so it's important to consider making your resume as machine-readable as possible: Minimal formatting, key technical terms should be abundant, standard date formats, etc. Only after this should consider how it reads naturally, and make any appropriate adjustments for subindustry (e.g. academically-focused jobs generally want to see education first, etc.) and company.
[1]: https://www.sovren.com/resume-job-parser/