Comment by subpixel

I haven't found an article or comment that gives me any insight into what Ms. Holmes might have been thinking. Did she earnestly believe she was on the cusp of some breakthrough, or that one was inevitable with enough brute-force application of investor money? Or was she shrewd and cunning to the core, calculating that she could siphon off enough money to make it worthwhile and spend enough money to spin the facts? I'm totally perplexed trying to put myself in her shoes and understand her motivation.