> Small study
Almost entirely irrelevant, provided it's properly powered--and based on the effect size and p-values, it is. Furthermore, for an 18 month trial, 40 people is larger than most.
> probably not preregistered
I mean, true, and we should definitely promote pre-reg, but, 1. so few are preregistered that I'm not sure it's prudent to disregard a study based on this and 2. it's an academic study, neither a clinical trial nor a public-health decree--not a typical study type that necessitates pre-registration.
> Likely Publication Bias or p-hacking.
What? You're arrived at this conclusion based on... the fact that it's "small" and you couldn't find preregistration about it?
> I'm starting to get interested when it's been independently replicated.
Yeah, if only there were another trial that showed a positive cognitive effect of bioavailable curcumin... https://www.ncbi.nlm.nih.gov/pubmed/25277322
I mean, the title of this post is by far the most wrong thing about this article, as...
1. it's not turmeric, it's curcumin, which is about 2% of turmeric by mass (so, you'd need to eat ~4.5g turmeric daily to match study doses).
2. curcumin doesn't even have any reasonable bioavilability by itself, so they're using a bioavailable analogue.
Almost entirely irrelevant, provided it's properly powered--and based on the effect size and p-values, it is. Furthermore, for an 18 month trial, 40 people is larger than most.
> probably not preregistered
I mean, true, and we should definitely promote pre-reg, but, 1. so few are preregistered that I'm not sure it's prudent to disregard a study based on this and 2. it's an academic study, neither a clinical trial nor a public-health decree--not a typical study type that necessitates pre-registration.
> Likely Publication Bias or p-hacking.
What? You're arrived at this conclusion based on... the fact that it's "small" and you couldn't find preregistration about it?
> I'm starting to get interested when it's been independently replicated.
Yeah, if only there were another trial that showed a positive cognitive effect of bioavailable curcumin... https://www.ncbi.nlm.nih.gov/pubmed/25277322
I mean, the title of this post is by far the most wrong thing about this article, as...
1. it's not turmeric, it's curcumin, which is about 2% of turmeric by mass (so, you'd need to eat ~4.5g turmeric daily to match study doses).
2. curcumin doesn't even have any reasonable bioavilability by itself, so they're using a bioavailable analogue.