I agree with points 1-3, but I would be remiss not to mention, that with respect to point 4, diseases like sickle cell anemia, which is hideously painful and fatal as a double inheritance (25% homozygous offspring in a heterozygous pairing, ss), but a wonderful defense against malaria in heterozygous offspring (Ss, 50% of said pairing). The remaining 25% homozygous wild-type (SS) are healthy, except when encountering malaria.
I would think that a mendelian genetic disease like sickle cell might well be on our hit list for all the trouble it causes. Of course, it could be argued that mosquito nets and drugs (i.e. technology) are a better, less costly defense, than these inborn genetic mutations.
https://www.cdc.gov/malaria/about/biology/sickle_cell.html
I would think that a mendelian genetic disease like sickle cell might well be on our hit list for all the trouble it causes. Of course, it could be argued that mosquito nets and drugs (i.e. technology) are a better, less costly defense, than these inborn genetic mutations.