Yes, you can. Maybe you even should, because then you at least understand all the moving parts. Because there are way too many shitty SPAs out there that break functionality (Twitter and Facebook when hitting the back button) or are annoyingly slow and unreliable (iTunes Connect, Play Developer Console). Read [1] to see all the disadvantages and understand them. Then maybe build an SPA.
[1]: https://adamsilver.io/articles/the-disadvantages-of-single-p...