It would be great to have a game like Eve where there's a "race" that consists of an AI controlling NPC bots scattered throughout the galaxy. Either an "evil" AI or a "benevolent dictator" AI.
Or even better, an AI controlling human players (creating tasks, rewarding, punishing, etc) towards a goal.
Or even better, an AI controlling human players (creating tasks, rewarding, punishing, etc) towards a goal.