Our diet is full of fruits and vegetables containing thousands of complex chemicals, indistinguishable from "synthetic" chemicals, that have entered our diet far too short a time ago to have had evolutionary impact.
If one wanted they could surely distill many chemicals in isolation from these naturally occurring fruits and vegetables that in concentration would have many concerning health effects. The fact that many don't worry about this is largely because this research program has not been attempted.
Point being, there is no reason to hold any of these chemicals to a standard higher than that of a strawberry - that is, we can give people a bunch of strawberries and say any negative effect is below some acceptable level. And, in fact, we have found many "natural" foods containing absurdly high levels of arsenic and other dangerous compounds, and that has affected their preparation for consumption. The scientific process has in this way even outperformed the naturalism heuristic.
If one wanted they could surely distill many chemicals in isolation from these naturally occurring fruits and vegetables that in concentration would have many concerning health effects. The fact that many don't worry about this is largely because this research program has not been attempted.
Point being, there is no reason to hold any of these chemicals to a standard higher than that of a strawberry - that is, we can give people a bunch of strawberries and say any negative effect is below some acceptable level. And, in fact, we have found many "natural" foods containing absurdly high levels of arsenic and other dangerous compounds, and that has affected their preparation for consumption. The scientific process has in this way even outperformed the naturalism heuristic.