Comment by ptoomey3

Once you have malicious software running it is largely game over. Sure, the hardware token can require a press..but once pressed what challenge is being signed? Malware can just wait and send a challenge for Site A when you are actually trying to sign into site B. Or, the malware can just wait until you login and steal your browser cookies. Oh, also, Soft U2F can require a similar physical touch if you have a mac with Touch ID.