HN is probably the wrong forum for health advice, as it's not really something you'd "hack". Your best bets are mostly mundane according to the large, peer-reviewed studies that have been done, and you could summarize them as:
* Eat a balanced diet, avoiding excess
* Exercise regularly, avoiding excess
* Don't smoke
* Don't drink more than a glass of alcohol each day, if at all
* Eat a balanced diet, avoiding excess
* Exercise regularly, avoiding excess
* Don't smoke
* Don't drink more than a glass of alcohol each day, if at all
* Cross your fingers and hope for the best