Not sure what you mean by "beyond Google Sheets" space, but there have been some cool spreadsheet tools emerging recently.
http://www.alphasheets.com/ is still mostly in stealth (as far as I can tell) but they let you mix and match SQL, Python, R, and Excel formulae in a spreadsheet.
http://www.alphasheets.com/ is still mostly in stealth (as far as I can tell) but they let you mix and match SQL, Python, R, and Excel formulae in a spreadsheet.
Airtable seems pretty polished (https://airtable.com/).
Both of these are definitely spreadsheets, though. Not sure if you're looking for something more specialized for a certain vertical or problem domain.