I use f.lux on a rather high setting 24/7 at work, most of the day at home (where I have better lighting), and at night on my phone. Using it all day at work with the 20/20/20* rule has greatly reduced my eye stress.
* I made a simple website using the Notifications API which reminds you every 20 minutes to take an eye break.
* I made a simple website using the Notifications API which reminds you every 20 minutes to take an eye break.
https://johnbartos.github.io/eyebreak/