Considering that natural selection is generally considered to not operate on post-reproductive phenotype (prime case is antagonistic pleiotropy literature) I consider any conclusion based on these measures pretty suspect. Worse, specific heritability for these traits in this cohort, as far as I can tell, wasn't even estimated. Given that the supplemental says the mean in the literature is 40%, it could very well be sub 20%.
I suspect that selecting only known high effect QTLs would actually not impact your power all that much as it limits the number of tests performed. If you can't see selection at high effect alleles I'm not sure you'll be able to detect them in aggregate either, especially with very noisy phenotype data.
At the end of the day natural selection is a change in allele frequency driven by differences in phenotype. Sure, this maybe was an easy analysis to do given that the data was available, but I don't really see the value.
I suspect that selecting only known high effect QTLs would actually not impact your power all that much as it limits the number of tests performed. If you can't see selection at high effect alleles I'm not sure you'll be able to detect them in aggregate either, especially with very noisy phenotype data.
At the end of the day natural selection is a change in allele frequency driven by differences in phenotype. Sure, this maybe was an easy analysis to do given that the data was available, but I don't really see the value.