I would think that really depends on the school and the person. When I was at University of Chicago, I knew a 16-year-old girl who had been homeschooled, and she had tons of friends and fit in really well. On the other hand, I was 17 and much less social and well-adapted (and I went to 12 years of public school).
I don't know if a 16-year-old would fit in as well at a big party school where they'd never be able to partake in much of the social scene (legally), though.
I don't know if a 16-year-old would fit in as well at a big party school where they'd never be able to partake in much of the social scene (legally), though.