I have the luck of having written GPU code on the base pixel shader on a title (Halo 4) that sold on the order of 10 million copies, first game I ever worked on. A back of the envelope calculation for how many times this code has been executed since 2012:
1e7 copies * 10 hours * 60 minutes * 60 seconds * 30fps * 1280 * 720 ~~ 300 quadrillion