Depends on the audience and the application. As Photoshop and AutoCad are both mentioned, I think that's the benchmark and not something like Facebook that wouldn't benefit as much from running as a desktop client.
On a side-note, didn't Facebook just release a new UWP app and didn't they regret going the HTML5 route to start with (not focusing on native apps)?
On a side-note, didn't Facebook just release a new UWP app and didn't they regret going the HTML5 route to start with (not focusing on native apps)?