Mostly around communication. Slack and IMs and video chat are great and all, but you can move way more information and have it be received much more clearly in person. There also can be a feeling of isolation, depending on how teams are structured and how many employees at the company are remote.
Also, there is no "going to the bar after work for a couple beers", which for many is fine. But still humans require some measure of being physically near other humans, so you need to be much more proactive about socializing and seeing friends/family. If you aren't diligent about this you can become kind of a hermit. If you have young kids this is probably not a big deal, you'd be too busy anyway.
Plus, like I mentioned before, you're now on the hook for the office space. Working remotely can lead you to justify paying for more house or apartment than you otherwise would have, because "well I need an extra room for my office". The freedom it affords is quite nice, so many would probably be fine with the extra outlay. But you should be clear about what you're paying for, and why.
Also, there is no "going to the bar after work for a couple beers", which for many is fine. But still humans require some measure of being physically near other humans, so you need to be much more proactive about socializing and seeing friends/family. If you aren't diligent about this you can become kind of a hermit. If you have young kids this is probably not a big deal, you'd be too busy anyway.
Plus, like I mentioned before, you're now on the hook for the office space. Working remotely can lead you to justify paying for more house or apartment than you otherwise would have, because "well I need an extra room for my office". The freedom it affords is quite nice, so many would probably be fine with the extra outlay. But you should be clear about what you're paying for, and why.