We work out of a mono-repo and use pants (https://pantsbuild.github.io/) for python/jvm/js packaging to deploy on mesos (https://mesos.apache.org/). Pants gives us (effectively) the same development workflow as in production and let's us treat any application (we have ~500 at this point) as just a command line executable (for things with weird lib dependencies, we do statically compiled wheels for each architecture - CentOS and OS X in our case - on our own pypi mirror). We've got a few kinks to still workout for local development of web projects (mostly related to JS/CSS) but for things that don't touch the frontend it's pretty beautiful.
We work out of a mono-repo and use pants (https://pantsbuild.github.io/) for python/jvm/js packaging to deploy on mesos (https://mesos.apache.org/). Pants gives us (effectively) the same development workflow as in production and let's us treat any application (we have ~500 at this point) as just a command line executable (for things with weird lib dependencies, we do statically compiled wheels for each architecture - CentOS and OS X in our case - on our own pypi mirror). We've got a few kinks to still workout for local development of web projects (mostly related to JS/CSS) but for things that don't touch the frontend it's pretty beautiful.