One of the factors that influences human flourishing is the prevalence of malaria nearby. If you get malaria and die, your ability to improve your own circumstances falls to 0.
"People now have access to bed nets which make them less likely to get malaria and die" seems like it would count as a systemic change.
"People now have access to bed nets which make them less likely to get malaria and die" seems like it would count as a systemic change.